One of the major challanges I have had with my TV / Media Center setup has been that in order to use Plex and my Google TV device for my media archive I needed to have two remotes. One universal remote (Harmony One) for all my compoents except for the Sony Google TV. This has been a minor annoyance for me however MC would prefer a simple setup.
She has been ok with the 2 remote setup but as I attempt to get rid of our Tivo and move to a different way to watch and record live TV i want to ensure we simplify and get everything down to one remote control. I have settled for now on using Kodi for everything TV related. Kodi has a plug in for Plex to allow me access to my media library. It also has a plugin for HDHome Run to allow live TV streaming from the cable card HDHomeRun PRIME.
I got harmony home control to work with Kodi on Mac using Flirc and my tv with Bose. Getting everything to run on one remote proved challenging but I got it working well enough to be ready to turn off the Google tv / TiVo setup I have.